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doi: 10.1016/j.lfs.2022.121072

Intracerebral hemorrhage injury mainly results from the secondary injury followed hematoma formation including hemoglobin cytotoxicity and explosive inflammatory response, which mainly resulted in brain edema and neuron death (Shi et al., 2012

With increasing hepatic dysfunction, the GH signaling cascade and hepatocyte IGF-I synthesis becomes impaired (124)

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