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The preferential response in ALD and in patients younger than 60 years with higher baseline MELD, preserved albumin (2.5 g/dL) and no HCCdefining the ideal responder profile is biologically plausible

GLP-1 receptor agonists trace their roots back to exendin-4, a peptide isolated from Gila monster venom in the early 1990san insight that eventually led to exenatide and reshaped the treatment of diabetes and metabolic disease

[16] Hypercholesterolemia was reported in 3.5% of postmenopausal women with operable breast cancer who received adjuvant tamoxifen therapy (n = 3094) in the ATAC trial

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Patients who typically eat rapidly or consume large meals may experience more pronounced symptoms initially because semaglutide's stomach-slowing effects become more noticeable with bigger food volumes

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