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Figure 6 Having demonstrated that metformin treatment significantly inhibits oxidative phosphorylation in both in vitro and ex vivo models of rectal cancer, the effect of metformin on histologically-confirmed normal rectal tissue biopsies ( n =12, median age of 41.5 y) taken from non-cancer patients was assessed in real-time using the Seahorse XFe analyser

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TGF induces SIK to negatively regulate type I receptor kinase signaling