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Pancreatitis: Case studies and a few of the clinical trials on GLP-1 RAs for diabetes have raised the possibility of pancreatitis being triggered by these drugs due to the potential growth in cells in the pancreas
Nat Rev Endocrinol (2011) 7(9):5056
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Hyperammonemia develops when ammonia production surpasses its elimination through the urea cycle, which relies on five key enzymes including carbamoyl phosphate synthetase 1, ornithine transcarbamylase, argininosuccinate synthase, argininosuccinate lyase, and arginase 1 [34]