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Contraindications, precautions : The drug should never be taken by pregnant women, patients with early hereditary optic nerve atrophy, hypersensitivity to cyanocobalamin, hypersensitivity to cobalt

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doi:10.1002/fsn3.1818 Yektas C, Alpay M, Tufan AE

51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

It's worth noting, however, there are no examples of severe illness that have been traced back to reusable water bottles in the scientific literature