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This webinar with obesity medicine physician Jonathan Bonnet, MD, MPH, a GLP-1RA expert, will answer your questions about the medications, how they work, their benefits, their side effects, and how they can be combined with lifestyle changes to optimize your weight loss and body composition
Food and Drug Administration (FDA) officially approved the GLP-1 medication Ozempic to help reduce the risk of worsening kidney disease in adults with type 2 diabetes and chronic kidney disease
Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly
