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NADPH is the major reducing equivalent driving de novo synthesis of fatty acids, cholesterol, amino acids, and nucleotides
Science (New York, N.Y.) 2004;Vol
On the other hand, ferroptosis within the TME can paradoxically foster tumor progression by impairing the antitumor functions of immune cells such as natural killer (NK) cells and cytotoxic T lymphocytes, and by promoting an immunosuppressive landscape
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