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This is underscored by the results of a clinical trial comparing the development of obese adults who received either semaglutide or liraglutide in addition to nutritional advice and physical activity, and significantly greater weight loss was achieved in the semaglutide group [102]

Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development

This makes it a strong option for those struggling to keep their diabetes under control

Eder K, Baffy N, Falus A, Fulop AK