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The randomized controlled trials (RCTs) summarized in Table 2 consistently demonstrate that GLP-1RAs, such as exenatide, semaglutide, and dulaglutide, significantly reduce albuminuria in patients with T2DM and CKD

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-glutaredoxin upregulated the expression of the Nrf2 pathway and its downstream enzymes (CAT, SOD), enhanced endogenous antioxidant defence, increased GSH levels and reduced ROS accumulation [125]

Among them, there are many bacteria associated with SCFA production that cause changes in SCFA levels