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Additionally, the agency has received adverse event reports that may be related to patients prescribed compounded semaglutide or tirzepatide products in doses beyond what is in the FDA-approved drug label

combined with the impact of gastrointestinal reactions on the absorption and adherence of oral contraceptives, the risk is further amplified, particularly during the initiation or dose-escalation phases of tirzepatide (161, 162, 169)

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doi: 10.1016/S0140-6736(99)00775-8

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