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This mechanistic distinction means the compound could theoretically be combined with appetite-suppressing peptides for a protocol that simultaneously reduces energy intake (GLP-1) and restores adipocyte energy expenditure (NNMT inhibition) though this remains purely theoretical without published combination data

(2022, January 1)

Benefits are often greatest in individuals with existing B12 deficiency or suboptimal methylation

Full Answer: GLP-1 agonists like semaglutide and tirzepatide primarily reduce body weight by suppressing appetite and improving insulin signaling

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