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Collectively, these findings establish FBXL21 as a rhythmically expressed, clock-controlled gene that modulates circadian period of the clock by regulating CRY protein stability in opposition to FBXL3, with distinct roles in nuclear and cytoplasmic compartments (Yoo et al., 2013

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Cholestasis refers to a condition in which bile flow is reduced or blocked

Science 295:10111011 Pevec D, Novinscak T, Brcic L, Sipos K, Jukic I, Staresinic M, Mise S, Brcic I, Kolenc D, Klicek R, Banic T (2010) Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application