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[5] [6] However, retatrutide remains an investigational compound and has not been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for any clinical use
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The western blot analysis for CGRP (rabbit anti-CGRP, BML-CA1134, Enzo Life Sciences, Farmingdale, NY, 1:2000) and TH (mouse anti-TH, sc-25269, Santa Cruz Biotechnology, Santa Cruz, CA, 1:1000) on protein extracts from renal pelvis were performed as described above with 12% SDS-PAGE gel to quantify the extent of ablation of afferent sensory nerves and determine if there was any damage to the efferent adrenergic innervation due to selective A-RDN in the pelvic wall of the kidney
This gradual timeline is expected because treatment begins at a lower dose to reduce side effects, and it takes several weeks for the medication to reach a steady state
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It is generally recommended to start with a lower dose (e.g., 500 mg once or twice daily) and gradually increase as tolerated
