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These include a relative or absolute increase in glucagon secretion from alpha cells of the pancreas, elevated serum free fatty-acid concentrations, an impaired incretin effect (e.g., decreased secretion of glucagon-like peptide-1 [GLP-1]), enhanced renal reabsorption of glucose, and dysregulation of appetite control via decreased neurotransmitter response in the brain
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The fact that the venom is used towards members of the same species during the mating season may have favored the use of the endogenous gene as the most effective venom component
By comparison, the placebo group showed essentially no change (0.3% increase)
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