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Youre creating a cellular environment where the skin is less reactive and less prone to producing excess pigment in response to stressors

While this approach has been used to predict the membrane permeability of drug molecules 11,12,13 , it cannot reveal transport mechanisms or provide a trajectory of a permeating molecule across the bilayer, which are desirable information for pharmacophore optimisation

However, the underlying molecular mechanism needs to be further elucidated

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Not inherently

The GP practice is making a decision based on what is easiest for the surgery, not what is best for the patient