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However, this weakening action appeared less pronounced when Ipamorelin was introduced alongside ghrelin, pointing to the possibility that Ipamorelin may not only support gastric muscle contractility but may also offset negative actions caused by certain interventions

However, its whitening results are not permanent

Arch Int Physiol Biochim

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, 1996, vol

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice