These numbers are unprecedented in the history of obesity pharmacotherapy
The GLP-1 and GIP arms meanwhile drive insulin secretion and gastric-emptying delay in different tissues and on different timescales (PMID 39515565, PMID 41785010)
The first strategy, exenatide was the first GLP-1 analog introduced for the treatment of patients with type 2 diabetes
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Phase 2a MASLD trial (48 weeks, liver disease population) In participants with metabolic dysfunction-associated steatotic liver disease (formerly NAFLD/NASH), retatrutide demonstrated remarkable liver fat reduction
Selected Data 1) The research team of Ma et al compared the therapeutic effects of peptides Liraglutide, Tirzepatide, and GLP-3R when administered to db/db mice experiencing diabetic kidney disease