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Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation

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Regular exercise, particularly moderate-intensity aerobic activity and resistance training, stimulates endogenous antioxidant defenses including glutathione synthesis

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They also impact plant metabolism and are directly absorbed by roots (Halpern et al., 2015

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