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Tirzepatide is a dual agonist that targets glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

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Structural features of Cagri-bound active CTR complexes Previous structural analysis of CTR-Gs bound to rAmy revealed that the receptor complex was dynamic, adopting distinct states where the receptor was resolved into two major conformations, a bypass (55%, PDB: 7TYL) and CT-like (45%, PDB: 7TYI) conformation 15

Table 1 Constituents and characteristics of the COVID-19 vaccines

To expand the search for biological influences of disease, we sought to investigate if major protein differences were present in children affected with konzo as compared to unaffected individuals

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