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While there is no compelling evidence to demonstrate that GLP-1s medications lead to excess muscle loss, numerous pharmaceutical companies are still looking for ways to combine GLP-1 medications with other compounds to better maintain muscle mass

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(PubMed) Marcocci C, Kahaly GJ, Krassas GE, et al

Semaglutide maintains effectiveness over months and years because it works with natural hormone systems rather than overstimulating the nervous system

doi: 10.1016/j.nurt.2010.05.003 139 OnoreCCareagaMAshwoodP

(1 Trusted Source GLP-1 receptor agonists and the risk of fragility fractures in older adults with type 2 diabetes Go to source) Do GLP-1 Drugs Raise the Risk of Osteoporosis and Gout