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TRIUMPH-1 has closed: The main obesity trial (NCT05929066) completed enrollment in April 2026
*This medication is a compounded product and is not approved by the FDA
In Phase 2 trials, retatrutide produced approximately 24% mean weight loss at 48 weeks at 12 mg, compared with about 22.5% for tirzepatide at 15 mg in the SURMOUNT-1 trial though direct head-to-head data is not yet available
Administration occurs subcutaneously, typically in the abdominal area, thigh, or upper arm, rotating injection sites to prevent tissue irritation
Over 26 weeks, heavy drinking days fell by 41.1 percentage points in the semaglutide group versus 26.4 in the placebo group, a 13.7-point treatment difference that reached statistical significance