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Patients were assumed to receive initial therapies until HbA1c exceeded 7.5% and then treatment-intensified to basal insulin

NAFLD exacerbates hepatic and peripheral insulin resistance, predisposes to atherogenic dyslipidaemia and causes the systemic release of pro-inflammatory cytokines and hepatokines that can promote the development of T2DM

As a result, evidence for antioxidant action in humans remains largely indirect and inferred from animal models, underscoring the need for clinical trials that systematically quantify redox outcomes alongside behavioral endpoints

Morning administration allows flushing to resolve before evening social or professional contexts where visible side effects are undesirable

The knees are a common problem area