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Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S

Bottom panel: The activity of natural killer cells (NK cell cytotoxicity) increased at weeks 2 and 4 for both the low-dose (gray bars) and high-dose (striped bars) groups

The research basethough extensive, comprising over 100 published studiesis entirely preclinical (animal models and in vitro experiments)

Vitamin C supports antioxidant protection and inhibits melanin formation, glutathione promotes skin brightening within 4-6 weeks, and tranexamic acid can reduce pigmentation severity by up to 49% after 3 months of consistent use

doi: 10.1016/j.cbi.2025.111422 102 PatilVSHarishDRSampatGHRoySJalalpureSSKhanalPet al