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67 While current efforts focus on cancer, similar strategies may be adaptable to cardiovascular disease, where enhanced clearance of misfolded or damaged proteins could improve outcomes in heart failure and ischemic injury

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Neurotensin receptor type 1 and alcohol Since NTS1 inhibits D2R function and potentially regulates glutamate signaling, NTS1 is a promising therapeutic target for AUD

The elevated expression of 20S proteasome (increased PSMA6), which play an important role in the elimination of oxidized proteins, might be one of the mechanisms that account for reduced levels of oxidized proteins in male livers

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Evidence from 8 randomized controlled trials (6361 participants) also suggested these effects could be maintained for up to 3.5 years, although long-term safety data were limited