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With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium
Some biomarkers, for example the accumulation of phospho-tau proteins, or the decrease in A42 levels in the CSF, serve as excellent diagnostic markers but may be less valuable as evaluation tools for therapeutic development
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