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422 MCD inhibitors enhance mitochondrial antioxidative capacity by modulating malonyl-CoA levels, consequently reducing FAO and proton generation
Moreover, canagliflozin hindered the transition from the G1 to S phase in the cell cycle and downregulated the expression levels of key cell cycle regulators, including cyclin D1, cyclin D3, cyclin E1, cyclin E2, and E2F1
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The other important aim of modern anti-diabetic therapy is to reduce mortality risk and long-term complications of T2DM, such as cardiovascular, renal and neurological damage