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Additionally, histological assessment involved Tyrosine Hydroxylase (TH) staining in the substantia nigra to evaluate the integrity and potential restoration of dopaminergic neurons, with evaluations performed at 1 month and 3 months post-lesion

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Unfortunately, current specific small molecule screening targeting DAO is mainly focused on the effect of DAO on the N-methyl-D-aspartate (NMDA) receptor, 475,476,477 while neglecting the important role of DAO in generating H 2 S, which is also a new direction for future exploration of H 2 S targeted therapy