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This can show up as symptoms such as delayed growth and development (failure to thrive), regression in neuromotor skills (such as losing the ability to roll over or grasp objects), failure to maintain eye contact (even in an infant who previous could do so), general muscle weakness, lethargy, excessive sleepiness, feeding difficulties, and even brain shrinkage

The result is weight gain, metabolic dysfunction, and chronic fatigue

J Am Med Assoc

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Similarly, 8-hydroxy verrucarin A and chrysomycin A, both inhibitors of NF-B and of the Akt/GSK3 pathway (Liu et al., 2016), also counteracted the growth defect phenotype induced by Cys4p overexpression (Supplementary Table 4)