Microvasc Res 75(2):144154 Funahashi Y et al (2010) Notch regulates the angiogenic response via induction of VEGFR-1
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This, in turn, doubles the capacity of the available growth factors to promote signaling cascades necessary for mitogenesis (cell division), motogenesis (promotion of cellular motility), morphogenesis (structural development), neurogenesis (growth and development of nervous tissue), production of stem cells, and protection of a wide range of cells against injury
Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention
(3) Technical limitations: polymeric nanocarriers suffer from premature drug leakage
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