Koob GF, Volkow ND
Firstly because of the abundance of GLP-1 receptors in the brain, and secondly because the brain and the immune system communicate with all organs in the body (Lunenfeld-Tanenbaum Research Institute)
Because this was a short-term study and the liver substudy involved a small group, its uncertain what may occur with longer use or in more diverse populations
[114] randomized subjects to semaglutide or placebo to observe the change of liver fat from baseline to week 48, and found that semaglutide significantly reduced hepatic steatosis, improved liver enzymes and metabolic parameters, and had a positive effect on the diagnosis and treatment of NAFLD compared with placebo
The development of novel dual- or triple-receptor agonists that bind to the receptors not only for GLP-1 but also to the receptors for glucose-dependent insulinotropic polypeptide (GIP) and/or glucagon is intended to address different metabolic pathways for carbohydrate, lipid, and protein metabolism simultaneously
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