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Patients with significant bile acid diarrhea, severe pancreatic insufficiency, or active pancreatitis carry higher risk and may warrant closer monitoring or an alternative strategy entirely

I emphasize safety first (of course), but I dont let archaic governing bodies dictate the care I provide

This attenuates angiotensin II (Ang II)-induced oxidative stress, DNA double-strand breaks, and podocyte damage, which is closely related to the pathogenesis of CKD [81] (Table 2)

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N Engl J Med 377:644657 Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes