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"Principally, it [GLP-1] minimizes intrusive thoughts about food, urgency to respond to cravings and more mindfulness around choices based on how youll feel." "GLP-1 receptors in the brain work in part to increase the feeling of satiety, and the GLP-1 receptors in the stomach slow down gastric emptying, which increases fullness," explains Nadler

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Gallbladder events occurred in 16% of the MariTide-treated participants in the obesity cohort (versus 0% with placebo), with higher rates at the 420 mg dose

Most patients find that appetite suppression begins within hours to days, making smaller meals more comfortable anyway