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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

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However, a post-hoc analysis of the SURPASS 4 trial found that tirzepatide use led to a lower decline in the annual estimated glomerular filtration rate and reduced the composite kidney endpoint defined as an estimated glomerular filtration rate decline greater than 40% from baseline, renal death, kidney failure, or new-onset macroalbuminuria (HR 0.58, 95% CI 0.430.8)

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The idea was to find substances that might be able to alter human physiology

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[12] [13] The medication works through a dual mechanism of action

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Description L-Carnitine is an amino acid that is naturally produced in the body

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