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Furthermore, increased concentrations of LPS in the plasma of SLE patients in comparison to healthy controls suggests that elevated intestinal permeability contributes to this condition (Shi et al

2024 2025: Preclinical development (IMPD/IND readiness) In 2024, Cleara received a new capital injection which allowed it to pursue Pre-IND/IMPD studies for clinical translation

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Importantly, an additional experiment showed that LASSS-treated BSA (after the removal of un-reacted LASSS) exhibited nitration resistance to the optimal peroxynitrite-treatment (1:2000 ratio), as shown in supplementary Figure 2, suggesting a model that LASSS-induced chemical modification mechanism exerts a nitration-inhibitory effect on a wide range of proteins susceptible to tyrosine nitration

25 Note: Topical concentration for hyperpigmentation is typically 2%