LDN is a modulating tool of the neuroimmune axis causing higher reactivity of immune cells mediated by transient increases in the opioid growth factor [103, 104]
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Repeated exposure of guinea-pigs to contact allergens resulted in reduced local reactions (Boerrigter et al., 1987) with eventual diminution such that the skin reactions were almost non-existent
In turn, this GI slowdown can cause a domino effect that slows down waste elimination