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doi: 10.1128/JVI.01856-10 130 HalpinPWilliamsMVKlimasNGFletcherMABarnesZArizaME

Lipotropic injections are generally not recommended during pregnancy or breastfeeding, for people with a known allergy to any component of the formulation (including B12/cobalt), for those with certain kidney or liver conditions, or for those with certain medical conditions

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This is due to the presence of intrinsic factor, a glycoprotein in the digestive tract that limits the bioavailability of B12

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Studies have noted that vagotomy can inhibit the misfolding of alpha-synuclein in enteric neurons and reduce the appearance of PD symptoms in animal models (Uemura et al., 2018