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These include very long term effects beyond ten years, outcomes in younger populations who may use GLP-1s for decades, effects on bone health in older adults, and rare side effects that may only appear with widespread use over time

The anabolic data come from rodents, often in artificial catabolic states, using administration routes and durations designed to probe pharmacology rather than model therapeutic use

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Unlike TRT, which typically requires continuous use to maintain benefits, many peptide protocols can be cycled

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