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In obesity clinical trials, patients achieved approximately 15-21% weight loss over 72 weeks, with somewhat smaller weight reductions typically seen in diabetes trials

Biochim Biophys Acta 1758:14611474

Atoms are shown as color-coded circles with thick black outlines and bonds: hydrogen (hidden), carbon (grey), oxygen (red), nitrogen (blue).

Surprisingly, HFD-fed Dpp4 Gut/ mice demonstrate increased TG excursion during a LTT, despite olive oilstimulated increases in circulating levels of GLP-1

however, heart failure with reduced ejection fraction also has a regional cause

In the clinical trials of tirzepatide, 19% of older adults had constipation while using the drug, compared with about 6% of those on a placebo