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Melanotan-2 produces visible skin darkening after 710 days of daily dosing at 0.51.0 mg as melanin accumulates in melanocytes this is a cumulative structural change requiring repeated administration

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Biochem Biophys Res Commun (2011) 410(3):5816

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The disadvantages are that they are slightly less effective than injections and require daily instead of weekly administration. Novo Nordisk also outlined pricing arrangements they suggest will improve access to the Ozempic pill