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10.1007/s003359900223 90 SeldinM

Clinical trials show Contrave produces modest weight loss (510% body weight in responders over 56 weeks), with effects primarily through central nervous system modulation rather than slowed gastric emptying or incretin hormone stimulation

The article names a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, uncontrolled severe diabetes, severe renal impairment, and concurrent use of other weight-loss medications as contraindications

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