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Deletion of hypoxia-inducible factor-1 in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation

This indicates that when considering dose adjustments for LCPT before steady state, clinical judgement must take into account additional accumulation expected to occur

DeSouza C, Cariou B, Garg S, Lausvig N, Navarria A, Fonseca V

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Notably, NU-0129, composed of siRNA targeting the GBM oncogene Bcl2Like12 (Bcl2L12) and a gold nanoparticle core, was the first spherical nucleic acid (SNA) drug administered systemically

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