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Once inside the cell, the expectation is that haem-bound iron can be liberated through enzymatic cleavage of the porphyrin ring by haem oxygenase enzymes that are present in many bacterial species (Richard et al., 2019)

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Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients

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