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Interest in Retatrutide trial results is high because obesity and type 2 diabetes remain major areas of clinical research
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The Phase 2 trial used a relatively rapid bi-weekly dose escalation that may have contributed to higher GI event rates
DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) exhibit differential expression, while ten-eleven translocation methylcytosine dioxygenases (TET1-3) are downregulated in ectopic lesions and eutopic stromal cells, influencing 5-hydroxymethylcytosine levels and epithelial-mesenchymal transition
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