The common link is that GLP-1s activate receptors that then work on driving down metabolic risk factors through the following mechanisms: Enhancing glucose dependent insulin secretion Slowing gastric emptying and decreasing appetite Reducing postprandial glucagon and food intake UpToDate 2 : (1) ingestion of food results in (2) release of gastrointestinal peptides (GLP-1 and GIP: glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and (3) pancreatic beta cell hormones (insulin and amylin)
Nevertheless, there are notable worries
Tip #2: Watch What You Eat, Especially at First GLP-1 medications slow the movement of food through your gut, which is why most side effects are stomach-related: nausea, heartburn, that heavy "I ate too much" feeling
We've been using them safely in medicine for decades nicotine replacement, hormone replacement therapy (HRT), some pain medications, motion sickness drugs, certain heart treatments
Singh V, Mahra K, Jung D, Shin JH
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