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As no significant differences in serum homocysteine, cystathionine (Figures 4 and 5) or serine levels [60, 69, 70, 75] were observed in children with autistic disorder compared to those without, it can be inferred that the low levels of cysteine may be caused by decreased cystathione lyase activity and/or increased utilisation of sulphate and/or taurine and/or lower dietary intake or absorption of cysteine in children with autistic disorder
In the case of iron overload, the loss of SLC7A11 contributes to ferroptosis-related liver injury ( function, triggering ferroptosis in cancer cells derived from the liver, kidney, and lung ( in vivo , whereas SLC7A11 / embryonic fibroblasts underwent cell death in routine culture medium in vitro but could proliferate normally in the presence of 2-mercaptoethanol (2ME), N-acetyl cysteine (NAC), or vitamin E ( Inhibition of GSH synthesis triggers ferroptosis
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Yen MC, Chou SK, Kan JY, Kuo PL, Hou MF, Hsu YL
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