SGLT2 inhibitors (sodium-glucose co-transporter-2 inhibitors) such as dapagliflozin, empagliflozin, or canagliflozin work via a complementary mechanismpromoting glucose excretion through the kidneys
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10.1210/en.2003-1014 Endocrinology 72 HeldtS
The gut microbiota synthesizes neurotransmitters such as 5-HT and GABA, which can interact directly with the nervous system or modulate the host neurotransmitter production, thereby influencing neurological processes (Erny et al., 2015)
Long-term studies in animals to evaluate carcinogenic potential have not been done