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Many investigators in this space use both, with appropriate single-compound controls

Paraxanthine, a less-studied CAF metabolite, has distinct pharmacokinetic and pharmacodynamic properties [6, 12] increasing dopaminergic activity [22] and potentially improving memory consolidation more effectively than caffeine

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It was therefore decided during the study to fill up the 0.2 mg dose group (A) first to get six evaluable subjects at this dose