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Karakasis P et al

10.1016/j.jacc.2024.10.091 J Am Coll Cardiol

GLP-1 medications work by slowing gastric emptying and increasing feelings of fullnessthat's their mechanism of action

Whether GLP-1RAs exert direct modulation of the hypothalamic-pituitary-ovarian (HPO) axis beyond these metabolic pathways remains to be verified by clinical mechanistic evidence