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Smoking has also emerged as a major risk factor for hepatocellular carcinoma (HCC) in PBC, with current smokers showing more than a twofold increased risk of HCC (adjusted HR: 2.31

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Importantly, selfotel is a glutamate antagonist

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Combining two ingredients that both have GI side effect potential could theoretically worsen tolerability, particularly during the early dose titration phase when the body is still adjusting to tirzepatide