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Similarly, GSH-activatable synthetic ion channels undergo GSH-mediated disassembly to release channel-forming compounds, leading to caspase-dependent apoptosis 217

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Factors that contribute to impaired gut barrier function include exposure to reactive food components (eg, gluten), dysbiosis, bacterial or fungal overgrowth in the gut, certain medications (eg, NSAIDs), and chronic inflammatory states, such as celiac disease and inflammatory bowel disease

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Briefly, the mice were anaesthetized by intraperitoneal injection of pentobarbital sodium (30 mg/kg) for nebulization